Marks and Spencer have announced they will be consulting on the closure of their Boston store.
Cllr Colin Davie, executive member for economy and place at Lincolnshire County Council, said: “This is very disappointing news for Boston.
“Our sympathies are with the 49 staff at the store, and, as always, we will work with our colleagues at the job centre and the local council to support those affected.
“Marks and Spencer is a big presence in the town centre, and we’ll play our part in finding a suitable alternative use for this unit, if the closure goes ahead.
“This news is a reflection of the difficulties currently facing high street retailers across the country.
“The future of our high streets is an issue that the council has looked at extensively, and we are ready to help them to evolve away from the traditional, retail-heavy model towards one that’s more fitting for the 21st century.
“That way we can give them a new lease of life, ensuring our town centres remain vibrant.”